Glycogen is a multibranched, carbohydrate storage molecule made up of monomers of glucose [1,2]. In periods of caloric extra, the extent of plasma glucose will increase and stimulates glycogen synthesis within the liver and skeletal muscle. Throughout caloric deficit, glycogen is quickly degraded to glucose to produce vitality manufacturing by way of glycolysis and the tricyclic acid (TCA) cycle . Coordinated regulation of glycogen synthesis and degradation is important for mobile homeostasis . Microscopic visualization of glycogen deposits in cells and tissue are essential within the prognosis of illnesses with aberrant glycogen metabolism. Interval acid-Schiff (PAS) optimistic/PAS-diastase (PAS-D) detrimental staining is probably the most generally used methodology for histochemical detection of glycogen by pathologists in a number of illnesses [4,5,6].Clinicians and pathologists have recognized giant glycogen granules in a number of cancers, but the importance of those deposits stays unknown. These aberrant glycogen accumulations have been recognized in cancers of the breast, kidney, uterus, lung, head and neck, bladder, ovary, and not too long ago, colorectal tumors [7,8,9,10,11,12,13,14]. Many PAS-positive tumors have earned the time period “clear cell” as a result of clear and ovoid look left by the carbohydrate accumulations within the cytoplasm after fixation and tissue preparation processing. A number of theories at the moment exist almost about the mechanism underlying glycogen metabolism adjustments in most cancers cells [15,16,17,18,19,20,21,22]. One widespread rationalization is that, underneath hypoxic situations within the heart of stable tumors, glycogen shops are elevated by way of hypoxia-inducible issue 1α (HIF1α) mediated signaling pathways to accommodate the low oxygen ranges and nutrient deprivation [13,18,23]. In recent times, most cancers analysis has highlighted a number of facets of metabolic re-wiring in malignant cancers with glycogen, not less than partially, contributing to those adjustments by offering a continuing provide of glucose. Whereas a number of pharmacological modulators of glycogen metabolism are at the moment being examined, none have but been clinically authorized .Breast most cancers is a heterogeneous illness accounting for 30% of all cancers identified in girls . Its routine classification/characterization relies on each histopathology (WHO acknowledges over 20 epithelial subtypes) and immunophenotypic/molecular options akin to estrogen receptor (ER), progesterone receptor (PR) and human epidermal receptor 2 (HER2) standing. Intriguingly, there are a number of uncommon histological variants of breast most cancers, considered one of which accommodates clear cells of epithelial origin. The optically clear cytoplasm in these cells could also be on account of numerous compounds akin to carbohydrate or lipid accumulations; with glycogen as probably the most generally recognized . Fisher et al. recognized glycogen accumulation in 100% of 45 clear cell carcinoma circumstances  and Hayes et al. reported 21 of 26 clear cell carcinomas had been glycogen-rich . Breast carcinoma with clear cytoplasm containing glycogen (PAS+/PAS-D−) recognized in additional than 90% of the tumor cells is classed as glycogen-rich clear cell carcinoma of the breast (GRCC) by the WHO .GRCC is taken into account an orphan illness because it accounts for lower than 3% of all breast carcinomas circumstances [26,27,29,30]. There was an ongoing debate over its prognostic implications. Fisher et al. recognized 45 circumstances of GRCC amongst 1555 girls with invasive breast most cancers . The research famous a poorer prognosis for GRCC sufferers, larger frequency of nodal metastasis, and better histologic grade (III) when in comparison with the 1510 circumstances of non-clear cell carcinomas . Nonetheless, 24 circumstances reported by Ma et al.  confirmed no vital distinction in general survival between GRCC and management invasive carcinomas when matched by age, tumor dimension, nodal standing, and immune-phenotype. Hayes et al.  reported 21 circumstances of GRCC and in addition discovered that prognosis was not completely different from non-GRCC when the tumor was matched by dimension, grade, and lymph node standing. As a result of lack of enough circumstances and inconsistency in out there information, classification of GRCC by way of prognosis is at the moment unclear [28,32]. Given the rarity of the circumstances at any given establishment, the Surveillance, Epidemiology, and Finish Outcomes (SEER) Program database offers a novel alternative to carry out giant population-based research on this orphan illness. This research takes benefit of the SEER program database for the retrospective evaluation of incidence, survival, demographics, and prognostic elements for GRCC of the breast.