Dr Andi: Caffeine Free Ketones/ High Blood Pressure/ Thyroid / Sleep

Dr Andi Campitelli has been a Naturopathic Doctor for 15 years and is a one of the foremost natural health experts on keto and a massive Pruvit fan… she does “Live Videos” each week answering questions about everything Ketone related…how to maximize your experience, troubleshooting, and how to feel your best.

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Does taking caffeine free ketones 2 times will give the same results?

If I only take caffeine free ketones twice a day, will I have the same results? Yes, you will. And it depends on the results that you’re looking for. But the caffeine doesn’t change the effectiveness of the ketones (beta hydroxybutyrate) in the actual product that you’re taking. So yes, absolutely, you will still get the benefit of having ketones in your system, whether you’re taking caffeine free or not.

Can you take ketones if you have high blood pressure?

Can you drink ketones if you have high blood pressure? There’s some really interesting research looking at the role of ketones; either through the ketogenic diet or having beta hydroxybutyrate in your system, with respect to blood pressure, cholesterol, waist, circumference, all of those things.  What the researchers have found is that people who have beta hydroxybutyrate in their system actually see greater improvement in those metabolic markers compared to those who maybe following a low fat diet or something like that. We actually do see benefits to blood pressure when we have it when we’re following a ketogenic diet or by consuming beta hydroxybutyrate…drinking ketones shouldn’t raise your blood pressure. Of course, if you have any medical condition at all, you have to talk to your health care provider, as it’s important that they say that that is safe for you to take; especially if you’re medicated as you want to make sure there are no interactions with any other ingredients in the product. Always speak to your healthcare provider to make sure they say it’s safe for you. I do have many patients with high blood pressure taking it, but again, everyone’s health is different so just check with your health care. 

Are ketones affected if anyone has taken out their thyroid?

Are ketones effective for someone without a thyroid? Yes, absolutely. For anyone who’s had their thyroid removed, there should be no issue at all with taking exogenous ketones. Also, no issue with the medications that would be prescribed after you’ve had your thyroid taken out. Obviously, thyroid meds are taken separately from every other medication and every other supplement, and that would apply as well to taking your ketones. Make sure you’re leaving the adequate space between medication and your ketones, but there’s no issue if you don’t have a thyroid and there shouldn’t be any problem with taking your exogenous ketones.

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Does ketones help someone to sleep?

What about someone who’s having trouble sleeping? if you’re taking ketone free or caffeine free nat, so usually the ketones are helpful to help somebody sleep the i mentioned earlier the signal of OSpm is very common with the 5-htp and things like that but the ketones themselves have also been shown to be very calming very it helps to trigger the release of GABA which is a very calming neurotransmitter. So usually we find that the ketones help somebody sleep even if they’re taking the caffeine free version. If that’s not the case for you then I just encourage taking it earlier in the evening.

we know that beta hydroxybutyrate is also a fuel for the brain and it causes a lot of it can make a lot of changes in terms of mental clarity brain fog that you might be experiencing during the day so if you’re finding that when you take it later in the evening it’s disrupting your sleep then just take it earlier in the day. So although that’s not a common outcome, I always say that anyone can respond to anything in any way. Just because it’s a typical response in most people doesn’t mean that that’s how every person will respond when they take it. It’s also entirely possible that some people will have the opposite effect from what we expect. So, if that’s you, the adjustment would be to be taken at a different time of day earlier and not close to bedtime. For an even deeper sleep,  you want to consider adding the Signal//OS PM tablets which are designed to improve sleep. 

You also might want to do a little trial and find out if it’s other ingredients in the ketones that are disrupting your sleep or is it the beta hydroxybutyrate itself? So maybe test by making up a Better Broth (US only) and sipping on it before bed to see if it disrupts your sleep.  This can help you identify if it’s the ketones or if it’s something else that’s affecting your sleep quality.

— Update: 30-12-2022 — cohaitungchi.com found an additional article Dangers of Exogenous Ketones: Read This Before Putting That in Your Mouth! from the website www.ketoaholics.com for the keyword prüvit ketones and hypothyroidism.

Do you really know what you’re’ getting into?

Sure, ketosis may be working for you, and you might want to kick it up a notch—but is supplementing with exogenous ketones really right for you?

If you don’t understand the dangers of exogenous ketones, you might be taking a serious risk. Be careful. Please take a few moments to read about the impacts of exogenous ketones before you decide to put them in your body.

You don’t even have to do the research. We’ve listed several hazards and side effects for you to sift through in the sections below:

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Prüvit ketones and hypothyroidism

#1: Increasing your likelihood of ketoacidosis

You might have heard of ketoacidosis, but do you understand what it is?

Ketoacidosis is a condition that happens when the ketone level in your blood rises too high. This can happen when your body is in ketosis.

Ketosis is a natural process that allows your body to create fuel from fat when carbohydrate sources aren’t available for body energy. (ref. 1)

Most of the time, ketosis isn’t dangerous. However, if you’re producing more ketones than you can use, Ketoacidosis can occur. This condition can be deadly. In people with diabetes, ketoacidosis occurs with a high blood sugar level and a lowered PH in the blood. (ref. 2)

Symptoms of ketoacidosis

For diabetics, some of the first symptoms you might notice are the same symptoms you experience when your blood sugar gets high: dry mouth, urinating a lot and experiencing excessive thirst.  You can also test your blood sugar. If it’s above 240 mg/dL, you may be in danger.

When this happens, it’s best to try to bring your blood sugar down. Check your ketone levels after about half an hour. Call the doctor if you’re concerned. (ref. 3)

If you experience these symptoms, get medical attention as soon as you can:

  • You’re vomiting, and it’s been more than two hours since the vomiting started.
  • You have a stomachache or feel queasy.
  • You feel tired and have brain fog or a woozy feeling.
  • Your breath smells fruity (this is a symptom of excess acetone, one of the three ketones produced in the body during ketosis) (4)
  • It’s hard to breathe.

Don’t take exogenous ketones if you have diabetes because diabetics can be more likely to develop ketoacidosis than non-diabetics.

The dangers of exogenous ketones include the risk of ketoacidosis. Ketoacidosis may ultimately result in coma and death. (ref. 5)

What can be done about ketoacidosis

If you get ketoacidosis, you’ll be dehydrated. One of the treatments you might receive could be an IV to rehydrate your body.

You might also need to take an electrolyte replacement to help raise your blood PH level too. This will help your internal organs function properly. A good electrolyte supplement might contain compounds like sodium, potassium, and chloride.

An important part of your treatment might include insulin to help bring down your blood sugar levels and reverse the processes causing your diabetic ketoacidosis. (ref. 6)

When is it safe to supplement with exogenous ketones while avoiding ketoacidosis?

Generally, if you do not have diabetes, the dangers of exogenous ketones may not be as harsh on your body. Just stay hydrated, keep an eye on your electrolytes, and watch out for symptoms of ketoacidosis just in case.

#2: Digestive issues

While not everyone using exogenous ketones gets tummy trouble, digestive issues might be the most common dangers of exogenous ketones.

Symptoms include:

  • Diarrhea
  • Nausea
  • Stomach pain
  • Dry retching
  • Reflux

There are a couple of reasons why exogenous ketones might be hard on your system. First, they don’t taste good. At all. Second, if your exogenous ketones include ketone salts, this can impact the way osmosis happens in your digestive tract and throw off normal functions. (ref. 7)

Take a look at your ketone supplement. Does it contain more ketone salts or more ketone esters? Keto salts tend to be a little harder on the digestive tract than keto esters are. (ref. 8)

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What can you do about it?

The best thing to do might be to start with small doses and work up to larger ones. Doses of about one teaspoon a day can slowly be upped to about two tablespoons a day. While you may still experience some gurgling, this stepped-up dosage can help alleviate the dangers of exogenous ketones. (9)

#3: Can exogenous ketones cause thyroid disorder?

Ketogenic diets were first suggested to help patients with epilepsy. A recent study looked at 120 patients with drug-resistant epilepsy on ketogenic diets. Because thyroid function changes during fasting periods, the study focused on the thyroid during ketosis.

The conclusion in this study indicated that ketogenic diets might cause hypothyroidism.  (ref. 10)

There are still a lot of unknowns about exogenous ketones. If one of the dangers of exogenous ketones is how it might impact your thyroid, ask yourself: Is it worth the risk?

#4: High blood pressure and keto salts

Low-carb diets can lower blood pressure. (ref. 11)

However, if you struggle with high blood pressure, check your exogenous supplement. If it contains keto salts, you may be putting yourself at risk of elevating your blood pressure even further.

#5: what are the dangers of exogenous ketones regarding blood cholesterol?

The ketogenic diet is a high-fat diet. (ref. 12) It’s also low in carbohydrates and proteins. (ref. 13)

The natural food sources containing MCT oils, like coconut oil, are saturated fats. (re. 14)

While this might be a reason to monitor the types of fats you’re taking in on your keto diet, does it have anything to do with exogenous ketones?

Since exogenous ketones only impact the number of ketones in your blood—not the type or amount of fat you eat—the dangers of exogenous ketones might not apply here. (ref. 15)

#6: How do exogenous ketones impact your blood sugar?

Ketone drinks can lower your blood sugar. This can be good in some cases, especially for people with diabetes looking for ways to control blood sugar spikes.

No real dangers of exogenous ketones here. (ref. 16)

#7: Reduced endurance in athletes

According to one study, a ketogenic diet, including those supplemented with the best keto products, can impair athletic ability. This might be because ketones reduce your body’s ability to use carbohydrates. (17)


Before you put that supplement in your mouth, consider the dangers of exogenous supplements. They might not be for you. If, after all this, you decide that they’ll work for you, make sure you get a high-quality supplement to support your ketosis. (ref. 18)

Prüvit ketones and hypothyroidism

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